What is Ozone Therapy (EBOO PLUS Technique)? How the procedure works and how it differs from conventional Ozone Therapy

Ozone Therapy (EBOO PLUS Technique) is an extracorporeal blood oxygenation and ozonation procedure. A portion of the patient’s blood is circulated through a sterile, closed system, where oxygen and medical ozone are added at a low, physician-controlled dose before the blood is returned slowly through a vein. At LINNA Clinic the procedure is only considered after a doctor-led consultation and an individual assessment.

This page explains how the procedure works, how a session is structured, and what your consultation covers. It is general information rather than medical advice: individual suitability is decided by a physician, individual responses vary, and no outcome is guaranteed.

What is Ozone Therapy (EBOO PLUS Technique)?

Extracorporeal Blood Oxygenation and Ozonation (EBOO PLUS Technique) circulates a portion of the patient’s blood through a sterile, closed external circuit, where it passes through a specialised filter and oxygen and medical ozone are added at a low, physician-controlled dose. The blood is then returned slowly through a vein.

Before any session, the doctor reviews your medical history, current health status and medications, together with laboratory results where appropriate, and decides whether the procedure is appropriate for you. Any supportive intravenous vitamins or nutrients are selected by the physician as part of an individualised plan.

Individual responses vary. Procedure parameters, session length and any supportive care are selected by the treating physician as part of an individualised wellness plan, and no outcome can be guaranteed.

Patients are encouraged to maintain healthy everyday habits — rest, nutrition, hydration and activity — alongside any plan agreed with the LINNA medical team.

How does Ozone Therapy (EBOO PLUS Technique) differ from conventional Ozone Therapy?

• Ozone concentration: Conventional ozone therapy often drips ozone from a bag into a vein at a high concentration of around 60–80 micrograms/cc. The EBOO PLUS technique instead adds ozone continuously at a low, physician-controlled concentration of roughly 0.1–0.5 micrograms/cc, not exceeding 2 micrograms — the defining difference between the two approaches.
• Research findings: Published research on continuous low-dose ozonation is limited and still developing, and findings are not conclusive. Your doctor can discuss the current evidence with you.
• Real-time monitoring: The EBOO PLUS system includes a detector that monitors the condition of red blood cells during the procedure. If an abnormality is detected, the doctor can stop the procedure immediately. Conventional ozone therapy generally lacks this real-time monitoring.
• Individual limitations: Suitability for people with blood-related conditions such as anaemia, thalassaemia or G6PD deficiency must be assessed individually by an experienced physician, and some individuals are not suitable candidates.

Individualised planning: The doctor carries out a detailed health assessment and, where appropriate, may recommend supportive vitamins or nutrients through a tailor-made IV drip as part of your individual plan.

What Are the Goals of an EBOO Wellness Program?

• Individualised wellness planning: The programme is designed as part of an individualised wellness plan agreed with your doctor.
• Physician-selected parameters: Ozone dose, session length and frequency are selected by the physician based on your clinical assessment.
• General wellness support: It may be considered alongside your wider health goals, rest, nutrition and follow-up care.
• Ongoing medical review: Progress is reviewed with the medical team and the plan adjusted where appropriate.
• No guaranteed outcomes: Individual responses vary, and no disease prevention or treatment outcome is implied or guaranteed.
• Consultation first: A medical consultation and suitability assessment are required before any treatment.

Who Should Consider a Medical Consultation Before EBOO?

• Anyone considering this procedure should begin with a consultation, so a doctor can review your medical history and any previous procedures
• Your current health status and symptoms
• All medications and supplements you take, including anticoagulants and antiplatelet medicines
• Laboratory results, where the physician considers them appropriate
• Pregnancy, bleeding or clotting conditions, and any known sensitivity to ozone
• Your personal health goals and expectations, so the doctor can explain what the procedure can and cannot address
• Suitability is decided by the physician’s assessment, not by the information on this page

Procedure and Process of Ozone Therapy (EBOO PLUS Technique)

• Extracorporeal circulation: A portion of the patient’s blood is drawn from a vein in the arm and circulated through a sterile filter and the oxygenation and ozonation circuit. The volume is decided by the physician for each individual.
• Medical oxygen and ozone: A medical ozone generator converts pure oxygen (O₂) into ozone (O₃), which is added to the circuit at a low concentration that the doctor controls carefully and adjusts for each patient.
• Return to the body: The blood is then returned through a vein in the other arm. The whole cycle runs in a closed, sterile system under continuous medical supervision until the session is complete.

How long does it take to do Ozone Therapy (EBOO PLUS Technique)?

A session usually takes about one hour. Most patients can resume their normal daily activities afterwards, and the doctor will give you individual advice based on your assessment.

How often should you do Ozone Therapy (EBOO PLUS Technique)?

Session frequency and ozone dose differ from person to person and are decided by the physician based on your assessment.

A commonly used schedule is one session every two weeks for an initial series, with follow-up sessions considered every few months if the doctor judges it appropriate.

Individual responses vary, and any plan is confirmed with your treating physician.

Safety & Medical Assessment

• Suitability must be assessed individually; the procedure is not appropriate for everyone.
• Potential risks, side effects and contraindications should be discussed with the doctor before you decide.
• Individual risk depends on your medical history, current health status and medications.
• The procedure is performed under medical supervision within a closed, sterile system.
• Ozone dose, flow rates and protocol are set and monitored throughout by the treating physician.
• Tell the doctor immediately if you feel unwell at any point during a session.

Who should take extra care or may not be suitable

• Pregnancy and breastfeeding: The procedure is generally not recommended during pregnancy or breastfeeding.
• Bleeding or clotting conditions: Tell the doctor in full about your history and current medications so your individual risk can be assessed.
• Known sensitivity to ozone: People with a known allergy or sensitivity to ozone should not undergo this procedure.
• Any case the physician advises against: If the assessment indicates the procedure is not appropriate for you, your doctor will discuss other options.

Please attend a consultation so a doctor can assess your case individually and discuss whether the procedure is appropriate for you, along with its risks and the alternatives available.

Protocol before and aftercare of Ozone Therapy (EBOO PLUS Technique)

The general guidance below may be discussed during your consultation. Your doctor’s individual instructions always take precedence.

Preparation before Ozone Therapy (EBOO PLUS Technique)

• Consult a doctor and undergo a detailed physical assessment to evaluate potential risks before receiving treatment.
• Get adequate rest and sleep for approximately six to eight hours.
• Stay hydrated: Drink plenty of water to promote good blood circulation.
• Avoid smoking and alcohol: Refrain from smoking and drinking alcohol for at least 24 hours before the treatment.
• Eat a light meal: Have a light meal at least 30 minutes before the procedure to maintain stable blood sugar levels.
• Tell the doctor about any vitamins or supplements you take, and follow the doctor’s instructions about them.
• If you take anticoagulants, antiplatelet medications, or other prescription medicines, inform the doctor before treatment. Do not stop or change prescribed medication unless instructed by your treating physician.

Self-Care after Ozone Therapy (EBOO PLUS Technique)

• Get plenty of rest: Allow your body to recover by getting adequate sleep.
• Eat a healthy diet: Consume a balanced diet rich in nutritious foods.
• Avoid alcohol and smoking: Refrain from drinking alcohol and smoking for at least three days after the treatment.
• Avoid heavy lifting: Avoid lifting heavy objects to prevent swelling, bruising, or bleeding at the needle insertion sites.

Ozone Therapy (EBOO PLUS Technique) at LINNA Clinic is carried out by our medical team as part of an individualised wellness plan, following a consultation and assessment.

To find out whether it is appropriate for you, book a consultation with a LINNA doctor on 063-609-8888 or via LINE: @linnaclinics.

This page is general information and not a substitute for medical advice. Individual suitability and responses vary, and no outcome is guaranteed.